Product Detail

Recombinant Human Growth Hormone(Somatropin) Injection


For Subcutaneous use. Growth hormone (GH), also known as somatropin (or as human growth hormone [HGH] in its human form), is a peptide hormone that stimulates growth, cell reproduction, and cell regeneration in humans and other animals. It is thus important in human development. It is a type of mitogen which is specific only to certain kinds of cells. Growth hormone is a 191-amino acid, single chain polypeptide that is synthesized, stored, and secreted by somatotropic cells within the lateral wings of the anterior pituitary gland. GH is a stress hormone that raises the concentration of glucose and free fatty acids. It also stimulates production of IGF-1.A recombinant form of hGH called somatropin (INN) is used as a prescription drug to treat children’s growth disorders and adult growth hormone deficiency.

Composition : Each Kit of Hormotropin-12 contains :
4 Vials of Recombinant human growth hormone (somatropin) ................................................. 12iu each.
1 Vial of solvent for Reconstitution containing Sterile Water ................................................... 10 ml.
Before use, dissolve dry substance in 1ml or as per your desired volume of solvent by gentle mixing.

Description :
Hormotropin-12 is a sterile, white or nearly white lyophilized powder for injection, The Solution is colourless after reconstitution.

Functions :
Effects of growth hormone on the tissues of the body can generally be described as anabolic (building up).Like most other protein hormones, GH acts by interacting with a specific receptor on the surface of cells. Increased height during childhood is the most widely known effect of GH. Height appears to be stimulated by at least two mechanisms :
Because polypeptide hormones are not fat soluble, they cannot penetrate cell membranes. Thus, GH exerts some of its effects by binding to receptors on target cells, where it activates the MAPK/ERK pathway. Through this mechanism GH directly stimulates division and multiplication of chondrocytes of cartilage.GH also stimulates, through the JAK-STAT signaling pathway, the production of insulin-like growth factor 1 (IGF-1, formerly known as somatomedin C), a hormone homologous to pro insulin.The liver is a major target organ of GH for this process and is the principal site of IGF-1 production. IGF-1 has growth-stimulating effects on a wide variety of tissues. Additional IGF-1 is generated within target tissues, making it what appears to be both an endocrine and an autocrine /paracrine hormone. IGF-1 also has stimulatory effects on osteoblast and chondrocyte activity to promote bone growth. In addition to increasing height in children and adolescents, growth hormone has many other effects on the body :
* Increases calcium retention[citation needed], and strengthens and increases the mineralization of bone
* Increases muscle mass through sarcomere hypertrophy
* Promotes lipolysis
* Increases protein synthesis
* Stimulates the growth of all internal organs excluding the brain
* Plays a role in homeostasis
* Reduces liver uptake of glucose
* Promotes gluconeogenesis in the liver
* Contributes to the maintenance and function of pancreatic islets
* Stimulates the immune system
* Increases deionization of T4 to T3

Dosage :
Human growth hormone is measured in IU (international units) and mg (milligrams). 1 mg equals approximately 3 IU while 1 IU equals approximately 0.33 mg. The dosage depends on the goal. People generally use 2 IU per day for anti aging purposes, between 4 to 6 IU for bodybuilding, weight loss and fitness, between 8 to 16 IU is used for short duration to treat severe burns or recover after injuries. Doses below 3IU per day usually bring no side effects while people can notice the improvement of their skin, better sleep, more energy, eating junk food without gaining weight, etc. After several weeks at 4IU and above some people will start to feel some side effects of somatropin. Slight water retention can be noticed in your fingers, toes and face (HGH makes the muscle cells hold more water and are thus temporarily inflated). Some people occasionally feel tingling sensation in their fingers and palms - this is known as carpal tunnel syndrome. It is described in detail in the ”effects of HGH” section. In practice carpal tunnel syndrome is the only side effect which actually bothers the user. Most athletes simply ignore it and continue the cycle for as long as they can. If the carpal becomes unbearable, they lower the dose or discontinue use until the side effects are gone. It usually takes about 2-3 weeks for the carpal tunnel syndrome to completely disappear. When using 4IU and above, it is good to split the dose in two daily injections. Half in the morning and the other half in late afternoon. You should avoid taking HGH before bedtime because the body releases its endogenous HGH (3rd dose) when you falls asleep. If you take the dose before bedtime it might interfere with your endogenous HGH release.

Side effects :
Hypersensitivity : Occasionally pruritus or local skin rashes at injection site may occur. In these cases, growth hormone should be discontinued.
Endocrine system : A state of hypothyroidism may be developed or exacerbated during growth hormone treatment. Human growth hormone may induce a state of insulin resistance, regular urine test for evidence of glucose intolerance and/ or glycosuria is recommended. Other side effect, which are usually mild and transient in nature, include headache , swollen hands and feet due to fluid retention, redness and itching on the area of injection. Tingling, numbness or perhaps pain primarily in the finger due to pressure on the nerve, joint stiffness and joint pain, muscle pain, eye-sight problem, feeling sick or vomiting.
Rare : sign of raised intracranial pressure.

Overdose :
The recommended dosage of Hormotropin-12 , should not be exceeded. There is little information on acute or chronic over dosage with Hormotropin-12 Lyophilized Powder. Intravenously administered growth hormone has been shown to result in an acute decrease in plasma glucose. Subsequently , hyperglycemia was seen . It is thought that the same effect might occur on rare occasions with a high dosage of Hormotropin-12 administered SC. Long-term over dosage may result in sign and symptoms of acromegaly consistent with overproduction of growth hormone. When these symptoms occur, growth hormone should be discontinued or dosage lowered.

Storage :
Store in hermetic container between 2-8 ºC . Do not freeze . Keep out of reach of children.

Incompatibility :
This medical product must not be mixed with other medical products and should only be reconstituted in the supplied solvent.

Shelf Life :
48 Months.

How Supplied :
12iu / Vial x 4 Vials = 48iu , accompanying with 10ml vial of solvent for reconstitution.



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